SrasV1, 2020, Analysis, bibRecord, 000331

Recent discovery and development of inhibitors targeting coronaviruses

Identifieur interne : 000331 ( 2020/Analysis ); précédent : 000330; suivant : 000332

Recent discovery and development of inhibitors targeting coronaviruses

Auteurs : Thanigaimalai Pillaiyar [Allemagne] ; Sangeetha Meenakshisundaram [Inde] ; Manoj Manickam [Inde]

Source :

Drug Discovery Today [ 1359-6446 ] ; 2020.

RBID : PMC:7102522

Abstract

Human coronaviruses (CoVs) are enveloped viruses with a positive-sense single-stranded RNA genome. Currently, six human CoVs have been reported including human coronavirus 229E (HCoV-229E), OC43 (HCoV-OC43), NL63 (HCoV-NL63), HKU1 (HCoV-HKU1), severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV), and MiddleEast respiratory syndrome (MERS) coronavirus (MERS-CoV). They cause moderate to severe respiratory and intestinal infections in humans. In this review, we focus on recent advances in the research and development of small-molecule anti-human coronavirus therapies targeting different stages of the CoV life cycle.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102522

DOI: 10.1016/j.drudis.2020.01.015
PubMed: 32006468
PubMed Central: 7102522

Affiliations:

Links to Exploration step

PMC:7102522

Le document en format XML

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   |texte=   Recent discovery and development of inhibitors targeting coronaviruses
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Recent discovery and development of inhibitors targeting coronaviruses

Recent discovery and development of inhibitors targeting coronaviruses

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